Perennials, 25-60+ cm; fibrous-rooted (caudices branched). Stems 1 or 2-3, clustered, glabrous or leaf axils sparsely hairy. Basal leaves (and proximal cauline) petiolate; blades narrowly ovate to ovate (2-3 times pinnately dissected, ultimate lobes mostly linear to filiform), 50-80 × 30-50 mm, bases ± truncate or auriculate, ultimate margins entire or remotely dentate. Cauline leaves gradually reduced (petiolate or sessile, similar to basals). Heads 10-30+ in open, corymbiform arrays. Peduncles bracteate or ebracteate, glabrous. Calyculi 0. Phyllaries (13-)21, green, 4-6 mm, glabrous (tips sometimes hair-tufted). Ray florets 8-10(-13); corolla laminae 8-12 mm. Disc florets 35-50+; corolla tubes 2-3 mm, limbs 1.5-2.5 mm. Cypselae 0.75-1.5 mm, hairy on ribs; pappi 3-4 mm.

Flowering early May-mid Jun. Open areas along streams, rock outcrops in thin, granitic-derived soils; of conservation concern; 400-900 m; Ga., N.C., S.C., Va.

Packera millefolia is known only from granitic soils in the southern Appalachians. It is similar in overall aspect to the widespread P. anonyma; it differs by its 2-3 times pinnately dissected leaves.