Perennials or subshrubs, 12-25 cm; pilose-villous indument intermixed with short glandular hairs. Leaves (opposite or alternate): petioles 5-20(-50) mm; blades orbiculate, ovate, or ovate-deltate, 8-18(-21) × 6-12(-15) mm, margins serrate to serrate-lobed. Heads borne singly or (2-3) in corymbiform arrays, 7-8.5(-9) × 5-7(-8) mm. Peduncles 8-40 mm. Involucres campanulate. Phyllaries 14-21, linear-lanceolate to sub-lanceolate, 5.5-6.5 × 1.1-1.5 mm. Ray florets 0. Disc florets 35-60; corollas yellow, tubes 1.4-1.6 mm, throats subtubular to subfunnelform, 2-2.4 mm, lobes 0.6-0.7 mm. Cypselae narrowly oblanceolate to suboblanceolate, (2.5-)3-3.5 mm, margins thin-calloused, short-hairy; pappi usually inconspicuous, callous crowns, rarely of minute scales. 2n = 36.

Flowering spring-fall. Dry, rocky slopes; of conservation concern; 1800-2800 m; Calif.

Perityle inyoensis occurs in the southern Inyo Mountains. It is allied to P. megalocephala, which occurs at intermediate and lower elevations to the north and east of P. inyoensis.